DMCA. Copyrighted Work that you can Claim.
Base have 250 515 books.
Search: 


📙 Virtual Screening: An Alternative or Complement to High Throughput Screening?: Proceedings of the Workshop ‘New Approaches in Drug Design and Discovery’, special topic ‘Virtual Screening’, Schloβ Rauischholzhausen, Germany, March 15–18, 1999 by Claire M.R. Ginn, Peter Willett (auth.), Gerhard Klebe (eds.) — pdf free


In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design.
As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this request which is summarized in this publication.



About book:

About file:

  • File size: 7 380 649
  • Format: pdf


Security code:
Download button

Similar books results


High Throughput Screening: The Discovery of Bioactive Substances
High Throughput Screening: The Discovery of Bioactive Substances download pdf by Devlin J.P.

Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating...

Optimal High-Throughput Screening: Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research
Optimal High-Throughput Screening: Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research free pdf by Xiaohua Douglas Zhang

This concise, self-contained, and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing, and ...

High-Throughput Screening in Heterogeneous Catalysis
High-Throughput Screening in Heterogeneous Catalysis epub download by

In this first book to present every important aspect of this fascinating and developing field, the three editors A. Hagemeyer, P. Strasser and A. F. Volpe Jr. from Symyx Technologies have chosen a perfect mixture of distinguished, international authors fr...

Structural Proteomics: High-Throughput Methods
Structural Proteomics: High-Throughput Methods download pdf by Russell L. Marsden, Christine A. Orengo (auth.), Bostjan Kobe, Mitchell Guss, Thomas Huber (eds.)

Structural genomics is a newly emerging field that has arisen following the successful footsteps of the major sequencing efforts generally bundled under the heading "genomics". In Structural Proteomics: High Throughput Methods, readers are provided with a...

High-Throughput Next Generation Sequencing: Methods and Applications
High-Throughput Next Generation Sequencing: Methods and Applications download pdf by Kathleen E. Steinmann, Christopher E. Hart, John F. Thompson, Patrice M. Milos (auth.), Young Min Kwon, Steven C. Ricke (eds.)

Due to their novel concepts and extraordinary high-throughput sequencing capacity, the “next generation sequencing” methods allow scientists to grasp system-wide landscapes of the complex molecular events taking place in various biological systems, includ...

New High Throughput Technologies for DNA Sequencing and Genomics
New High Throughput Technologies for DNA Sequencing and Genomics free pdf by Keith R. Mitchelson (Eds.)

Since the independent invention of DNA sequencing by Sanger and by Gilbert 30 years ago, it has grown from a small scale technique capable of reading several kilobase-pair of sequence per day into today's multibillion dollar industry. This growth has spur...

Virtual Screening: Principles, Challenges, and Practical Guidelines (Methods and Principles in Medicinal Chemistry) volume 48
Virtual Screening: Principles, Challenges, and Practical Guidelines (Methods and Principles in Medicinal Chemistry) volume 48 pdf free by Christoph Sotriffer, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

A comprehensive and up-to-date overview, this is both a desktop reference and practical guide for virtual screening applications in drug discovery. Clearly divided into three major sections, the first on principles provides a detailed description of the m...

Structural Proteomics: High-Throughput Methods
Structural Proteomics: High-Throughput Methods free pdf by Raymond J. Owens (eds.)

This updated and expanded volume reflects the current state of the structural protein field with improved and refined protocols that have been applied to particularly challenging proteins, notably integral membrane proteins and multi-protein complexes. St...

Combinatorial Development of Solid Catalytic Materials: Design of High-Throughput Experiments, Data Analysis, Data Mining (Catalytic Science
Combinatorial Development of Solid Catalytic Materials: Design of High-Throughput Experiments, Data Analysis, Data Mining (Catalytic Science free epub by Manfred Baerns, Martin Holena

The book provides a comprehensive treatment of combinatorial development of heterogeneous catalysts. In particular, two computer-aided approaches that have played a key role in combinatorial catalysis and high-throughput experimentation during the last de...

Atlas of Chrysophycean Cysts
Atlas of Chrysophycean Cysts epub download by Katharine E. Duff, Barbara A. Zeeb, John P. Smol (auth.)

Chrysophycean algae are a diverse and often abundant group of primarily freshwater phytoplankton, characterized by the endogenous formation of siliceous cysts or stomatocysts (also called statospores or statocysts). Cyst morphology is highly variable, but...

Biotechnologie — Gentechnik: Eine Chance fur neue Industrien
Biotechnologie — Gentechnik: Eine Chance fur neue Industrien pdf free by Dr. Thomas von Schell, Prof. Dr. Hans Mohr (auth.), Dr. Thomas Von Schell, Professor Dr. Hans Mohr (eds.)

Allgemein werden den neuen Biotechnologien hohe Marktpotentiale eingeräumt. Umstritten sind jedoch die realen Wachstumschancen und die Zeitpunkte, zu denen biotechnologische Produkte der neuen Generation signifikante Marktanteile erreichen werden. Welche ...

Computer Aided Drug Design in Industrial Research
Computer Aided Drug Design in Industrial Research download pdf by G.-A. Hoyer (auth.), E. C. Herrmann, R. Franke (eds.)

The Ernst Schering Research Foundation sponsored its 15th workshop in Berlin on October 19-21, 1994. Leading scientists from Europe and North America were invited to discuss computer-aided drug design in industrial research. Computer-aided drug design is ...

Arctic and Alpine Biodiversity: Patterns, Causes and Ecosystem Consequences
Arctic and Alpine Biodiversity: Patterns, Causes and Ecosystem Consequences free pdf by M. D. Walker (auth.), Prof. Dr. F. Stuart Chapin III, Prof. Dr. Christian Körner (eds.)

As human populations expand and have increasing access to technol­ ogy, two general environmental concerns have arisen. First, human pop­ ulations are having increasing impact on the earth system, such that we are altering the biospheric carbon pools, bas...

Genetics and Biotechnology
Genetics and Biotechnology pdf free by R. H. Davis (auth.), Professor Dr. Ulrich Kück (eds.)

Current Issues in Plant Molecular and Cellular Biology: Proceedings of the VIIIth International Congress on Plant Tissue and Cell Culture, Florence, Italy, 12–17 June, 1994
Current Issues in Plant Molecular and Cellular Biology: Proceedings of the VIIIth International Congress on Plant Tissue and Cell Culture, Florence, Italy, 12–17 June, 1994 download pdf by B. Sigurbjornsson, M. Maluszynski (auth.), M. Terzi, R. Cella, A. Falavigna (eds.)

Plant cell and tissue culture is a relevant area of experimental biology that has been developed for some decades to become an indispensable tool of plant biotechnology. Progress in this area, sometimes tumultuous, has been regularly recorded by the proce...

Steroid Analysis
Steroid Analysis epub download by D. N. Kirk, B. A. Marples (auth.), H. L. J. Makin, D. B. Gower, D. N. Kirk (eds.)

The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy: Death from inside out
The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy: Death from inside out free pdf by Andrew H. Wyllie (auth.), T. M. Dexter, M. C. Raff, A. H. Wyllie (eds.)

The past five years have witnessed a remarkable development of interest in cell death 'from inside out'. After 30 years of relative obscurity, its quantitative importance in the building and maintenance of normal tissues, the subtle strategies involved in...

The Nervous Systems of Invertebrates: An Evolutionary and Comparative Approach: With a Coda written by T.H. Bullock
The Nervous Systems of Invertebrates: An Evolutionary and Comparative Approach: With a Coda written by T.H. Bullock free download by PD Dr. Dr. O. Breidbach, Prof. Dr. W. Kutsch (auth.), PD Dr. Dr. O. Breidbach, Prof. Dr. W. Kutsch (eds.)

In this volume outstanding specialists review the state of the art in nervous system research for all main invertebrate groups. They provide a comprehensive up-to-date analysis important for everyone working on neuronal aspects of single groups, as well a...

Funktionelle Pflanzenanatomie
Funktionelle Pflanzenanatomie epub download by Professor Walter Eschrich (auth.)

Funktionelle Pflanzenanatomie Das Besondere an diesem Lehrbuch ist, daß es die Strukturelemente der Pflanzen nach ihrer Funktion beschreibt. Auf diese Weise wird die Pflanzenanatomie mit den physiolo- gischen Prozessen, die in Pflanzen ablaufen, in Zusamm...